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New synthetic method for 4‐hydroxyproline
Author(s) -
De Martino Giovanni,
De Caprariis Paolo,
Abignente Enrico,
Rimoli Maria Grazia
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270306
Subject(s) - chemistry , hydroxyproline , pyrrolidine , hydrolysis , organic chemistry , biochemistry
A new synthesis of 4‐hydroxyproline was carried out starting from diethyl p ‐nitrobenzoylaminomalonate, which was converted by a three steps pathway into diethyl 4‐hydroxy‐1‐(4‐nitrobenzoyl)pyrrolidine‐2,2‐dicarboxylate, which afforded 4‐hydroxyproline via acid hydrolysis.
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