A convenient synthesis of 3‐aryl‐1,2,4‐triazolo[4,3‐ c ]quinazolines | Zendy

ElKerdawy Mohamed M. | Zendy; Ismaiel Abd ElKader M. | Zendy; Gineinah Magdy M. | Zendy; Glen Richard A. | Zendy

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A convenient synthesis of 3‐aryl‐1,2,4‐triazolo[4,3‐ c ]quinazolines

Author(s) -

ElKerdawy Mohamed M.,

Ismaiel Abd ElKader M.,

Gineinah Magdy M.,

Glen Richard A.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270304

Subject(s) - chemistry , bromine , aryl , acetic acid , alkoxy group , condensation , medicinal chemistry , organic chemistry , alkyl , physics , thermodynamics

The synthesis and characterization of several 3‐aryl‐1,2,4‐triazolo[4,3‐c]quinazolines is described. The first step comprises the condensation of aromatic aldehydes with 2‐(H or Cl)‐4‐hydrazinoquinazolines 2 to afford the corresponding hydrazones 3 . The second step involves the cyclization to the title compounds 4 in bromine/acetic acid. Reaction of 4 (X = Cl) with cyclic amines gave the corresponding 5‐cyclicamino 5 or 5‐alkoxy derivatives 6 .

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