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A convenient synthesis of 3‐aryl‐1,2,4‐triazolo[4,3‐ c ]quinazolines
Author(s) -
ElKerdawy Mohamed M.,
Ismaiel Abd ElKader M.,
Gineinah Magdy M.,
Glen Richard A.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270304
Subject(s) - chemistry , bromine , aryl , acetic acid , alkoxy group , condensation , medicinal chemistry , organic chemistry , alkyl , physics , thermodynamics
The synthesis and characterization of several 3‐aryl‐1,2,4‐triazolo[4,3‐c]quinazolines is described. The first step comprises the condensation of aromatic aldehydes with 2‐(H or Cl)‐4‐hydrazinoquinazolines 2 to afford the corresponding hydrazones 3 . The second step involves the cyclization to the title compounds 4 in bromine/acetic acid. Reaction of 4 (X = Cl) with cyclic amines gave the corresponding 5‐cyclicamino 5 or 5‐alkoxy derivatives 6 .