A new approach for the synthesis of pteridines: The synthesis of 3‐substituted‐2‐thioxo‐1,2‐dihydro‐4(3 H )‐pteridinones | Zendy

Urleb Uros | Zendy; Neidlein Richard | Zendy; Kramer Walter | Zendy

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A new approach for the synthesis of pteridines: The synthesis of 3‐substituted‐2‐thioxo‐1,2‐dihydro‐4(3 H )‐pteridinones

Author(s) -

Urleb Uros,

Neidlein Richard,

Kramer Walter

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270261

Subject(s) - chemistry , tautomer , nucleophile , scope (computer science) , medicinal chemistry , combinatorial chemistry , stereochemistry , computational chemistry , organic chemistry , catalysis , computer science , programming language

3‐Substituted‐2‐thioxo‐1,2‐dihydro‐4(3 H )‐pteridinones can be conveniently prepared by the reaction of methyl 3‐isothiocyanato‐2‐pyrazinecarboxylate 2 with N ‐nucleophiles. The scope and limitations of the method are presented. The tautomeric form of 2‐thioxo‐1,2‐dihydro‐4(3 H )pteridinones was determined on the basis of a 13 C‐[ 1 H]‐NOE experiment.

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