Reaction of  N ‐[(α‐acetoxy)‐4‐pyridylmethyl]‐3,5‐dimethylbenzamide with alkyl isocyanates | Zendy

Braña Miguel F. | Zendy; Castellano José M. | Zendy; Donoso Rosa | Zendy; López Rodríguez María L. | Zendy; Yunta María J. R. | Zendy; Walker Nigel P. C. | Zendy

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Reaction of N ‐[(α‐acetoxy)‐4‐pyridylmethyl]‐3,5‐dimethylbenzamide with alkyl isocyanates

Author(s) -

Braña Miguel F.,

Castellano José M.,

Donoso Rosa,

López Rodríguez María L.,

Yunta María J. R.,

Walker Nigel P. C.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270254

Subject(s) - chemistry , isopropyl , pyridine , alkyl , medicinal chemistry , crystal structure , organic chemistry , stereochemistry

Reaction of N ‐(α‐acetoxy)4‐pyridylmethyl]‐3,5‐dimethylbenzamide 3 with methyl and ethyl isocyanates afforded 1,3‐dimethyl and 1,3‐diethyl‐4‐(3,5‐dimethylbenzoylamino)‐2‐oxoimidazolidine‐5‐spiro‐4′‐[1′,4′‐dihydro‐1′‐acetyl]pyridine 6a,b , respectively. However, the reaction of 3 with isopropyl, t ‐butyl and phenyl isocyanates gave the corresponding N,N ′‐diurea and the dimerization compound 8 . The structure of 6a was confirmed by crystal X‐ray diffraction analysis.

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