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Bis heterocycles as potential chemotherapeutic agents. X . Synthesis of bis(4‐arylthiosemicarbazido)‐, bis(2‐arylamino‐1,3,4‐thiadiazol‐5‐yl) and bis(4‐aryl‐1,2,4‐triazolin‐3‐thione‐5‐yl)pentanes and related compounds
Author(s) -
Ram Vishnu J.,
Mishra Lallan,
Pandey N. H.,
Kushwaha D. S.,
Pieters Luc A. C.,
Vlietinck Arnold J.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270245
Subject(s) - chemistry , alkylation , hydrogen peroxide , aryl , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , alkyl
Synthesis of several bis(4‐arylthiosemicarbazido‐ 1 , bis(2‐arylamino‐1,3,4‐thiadiazol‐5‐yl)‐ 5 and bis(4‐aryl‐1,2,4‐triazolin‐3‐thione‐5‐yl)‐ 2 pentanes is described. Sulphides 3 and sulphones 4 are also prepared from 2 by alkylation and subsequent oxidation with hydrogen peroxide respectively.