Synthesis and  13 C NMR of (trifluoromethyl)hydroxypyrazoles | Zendy

Lee Len F. | Zendy; Schleppnik Francis M. | Zendy; Schneider Ronald W. | Zendy; Campbell Dwane H. | Zendy

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Synthesis and 13 C NMR of (trifluoromethyl)hydroxypyrazoles

Author(s) -

Lee Len F.,

Schleppnik Francis M.,

Schneider Ronald W.,

Campbell Dwane H.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270224

Subject(s) - trifluoromethyl , chemistry , methylhydrazine , pyrazole , carbon 13 nmr , nmr spectra database , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , medicinal chemistry , proton nmr , stereochemistry , organic chemistry , spectral line , alkyl , physics , astronomy , phenylhydrazine

Reaction of ethyl 4,4,4‐trifluoroacetoacetate with methylhydrazine produced not only the previously reported 5‐hydroxy‐3‐(trifluoromethyl)pyrazole 1 but also its unknown isomer the 3‐hydroxy‐5‐(trifluoromethyl)pyrazole 4 . The structure assignments are established based on 13 C nmr spectra. Compound 1 was converted to 5‐chloro‐3‐(trifluoromethyl)pyrazolecarboxylic acid 3 in two steps.

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