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Synthesis and cardiotonic activity of pyrimido[5,4‐ b ][1,4]oxazinones and 1,4‐dioxino[2,3‐ d ]pyrimidines
Author(s) -
Mátyus Péter,
Makk Nándor,
Tegdes Anikó,
Kosáry Judit,
Kasztreiner Endre,
Podányi Benjamin,
Rabloczky György,
Kiirthy Mária
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270207
Subject(s) - chemistry , pyrimidine , ring (chemistry) , stereochemistry , inotrope , medicinal chemistry , organic chemistry , medicine , endocrinology
The new pyrimido[5,4‐ b ][1,4]oxazinones 4a‐c and 6a,b, 7a,c were obtained from 6‐amino‐2,3‐dimethyl‐4(3 H )‐pyrimidone ( 1 ) and 4‐substituted pyrimido[5,4–6][1,4]oxazinones 5, 7a , respectively, while derivatives 8a‐e of the novel ring system 1,4‐dioxino[2,3‐ d ]pyrimidine were prepared starting from 2b . Compounds 4a, 4c and 7a showed positive inotropic effect.