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Reaction of nitriles under acidic conditions. Part VI . Synthesis of condensed 4‐chloro‐ and 4‐aminopyrimidines from ortho ‐aminonitriles
Author(s) -
Shishoo C. J.,
Devani M. B.,
Bhadti V. S.,
Jain K. S.,
Ananthan S.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270201
Subject(s) - chemistry , nitrile , furan , condensation , benzene , thiophene , hydrogen chloride , organic chemistry , chloride , substrate (aquarium) , medicinal chemistry , physics , oceanography , thermodynamics , geology
Condensation of a nitrile with benzene, furan and thiophene ortho ‐aminonitriles in the presence of dry hydrogen chloride yields condensed 4‐chloropyrimidines, condensed 4‐aminopyrimidines or a mixture of the two condensed pyrimidines in varying proportions depending upon the nature of the nitrile and the substrate, ortho ‐aminonitrile.