Premium
Synthesis of vinca alkaloids and related compounds. XLVI. . Formation of a new ring system
Author(s) -
Dancsó András,
KajtárPeredy Mária,
Szántay Csaba
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260662
Subject(s) - chemistry , vinca , indole test , ring (chemistry) , cyclopropane , pictet–spengler reaction , stereochemistry , medicinal chemistry , organic chemistry , pharmacology , medicine
In the Pictet‐Spengler reaction of indole‐3‐propanamine 1 and diethyl‐(2‐formyl‐cyclopropane‐1,1‐dicar‐boxylate) 2 the formation of ethyl (1a,2,4,5,6,11,11b,11c‐octahydro‐2‐oxo‐1 H ‐cycloprop[3′,4′]pyrrolo[1,2′:1,2]‐azepino[3,4‐ b ]indole‐1a‐carboxylates) 3 and 4 was observed. Compounds 3 and 4 represent a new ring system.