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Synthesis of 4,7‐disubstituted spirobenzofuran‐2(3 H )‐cyclohexanes
Author(s) -
Bradbury Barton J.,
Sindelar Robert D.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260655
Subject(s) - cyclohexanes , chemistry , regioselectivity , benzofuran , electrophile , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis
A general synthetic strategy was designed for the preparation of 7‐substituted‐4‐methoxy‐ and 4‐hydroxyspiro[benzofuran‐2(3 H )‐cyclohexanes] 5 and 6 (Figure 1) using successive, regioselective hetero‐atom‐facilitated aromatic lithiation reactions and subsequent reaction with various electrophiles.