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3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine
Author(s) -
Wigerinck Piet,
Van Aerschot Arthur,
Claes Paul,
Balzarini Jan,
De Clercq Erik,
Herdewijn Piet
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260624
Subject(s) - chemistry , substituent , cycloaddition , human immunodeficiency virus (hiv) , stereochemistry , organic chemistry , virology , biology , catalysis
Cycloaddition of different acetylenic compounds on the azido function of 3′‐azido‐2′,3′‐dideoxythymidine and 3′‐azido‐2′,3′‐dideoxyuridine afforded products with a 1,2,3‐triazol‐1‐yl substituent in the 3′‐position. In contrast with the parent compounds, these triazolyl derivatives had no appreciable activity against human immunodeficiency virus (HIV‐1).