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New quinoxaline and pyrimido[4,5‐b]quinoxaline derivatives. Potential antihypertensive and blood platelet antiaggregating agents
Author(s) -
Monge A.,
Palop J. A.,
Urbasos I.,
FernándezAlvarez E.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260621
Subject(s) - quinoxaline , chemistry , deoxygenation , platelet aggregation , nitrone , platelet , organic chemistry , medicinal chemistry , stereochemistry , combinatorial chemistry , immunology , biology , catalysis , cycloaddition
Starting with 3‐amino‐2‐quinoxalinecarbonitrile 1,4‐dioxide 1 , a new series of quinoxaline derivatives 2‐12 was synthetized through chemical modification of the 3‐amino group, the 2‐cyano group and selective mono‐deoxygenation of the 1‐oxide or 4‐oxide groups. On the other hand, two 2,4‐diaminopyrimido[4,5‐ b ]quinoxa‐line derivatives 13, 14 were obtained condensing 3‐amino‐2‐quinoxaline carbonitriles with quanidine. Some of the new compounds were studied as inhibitors of blood platelet aggregation as well as antihypertensive agents.