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A regiocontrolled synthesis of substituted indoles by palladium‐catalyzed coupling of 2‐bromonitrobenzenes and 2‐bromoacetanilides
Author(s) -
Kasahara Akira,
Izumi Taeko,
Murakami Satoshi,
Miyamoto Kazuhiro,
Hino Toshimi
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260533
Subject(s) - chemistry , palladium , catalysis , selectivity , coupling reaction , ethylene , coupling (piping) , organic chemistry , reaction conditions , combinatorial chemistry , mechanical engineering , engineering
Abstract The palladium‐catalyzed cross‐coupling reaction of 2‐bromonitrobenzenes or 2‐bromoacetanilides with ethylene has been used to produce a variety of substituted indoles. The mild reaction conditions and selectivity inherent in the coupling reaction have been utilized to produce regiochemically pure 4‐, 5‐, 6‐, and 7‐substituted indoles.