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A novel synthesis of 3‐Amino‐1,2‐benzisoxazoles — an entry into the isoxazolo[3,4,5‐ ef ][1,4]benzoxazepine ring system
Author(s) -
Shutske Gregory M.,
Kapples Kevin J.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260515
Subject(s) - chemistry , benzonitrile , ring (chemistry) , stereochemistry , combinatorial chemistry , organic chemistry
A novel synthesis of 3‐amino‐1,2‐benzisoxazole (3) from 2‐[(isopropylideneamino)oxy]benzonitrile (2) is described. This methodology was used to synthesize 3‐amino‐4‐hydroxy‐1,2‐benzisoxazole (10), which served as an intermediate for a number of isoxazolo[3,4,5‐ ef ][1,4]benzoxazepines.
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