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Carba‐acyclonucleoside antiherpetic agents
Author(s) -
Hannah John,
Tolman Richard L.,
Karkas John D.,
Liou Richard,
Perry Helen C.,
Field A. Kirk
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260510
Subject(s) - ganciclovir , chemistry , methylene , stereochemistry , side chain , combinatorial chemistry , human cytomegalovirus , biochemistry , organic chemistry , gene , polymer
Ganciclovir 2 and 2′‐carba‐ganciclovir 5a are anti‐viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy and fluoro derivatives of 2′‐carba‐ganciclovir were prepared to examine the effect of re‐introducing a binding site close to that in the original oxa side chain. The cyclic phosphate of carba‐ganciclovir was also prepared.