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Synthesis of potential antifilarial agents 2 . methyl 2‐substituted purine 8‐carbamates and related compounds
Author(s) -
Ram Siya,
Evans William,
Wise Dean S.,
Townsend Leroy B.,
Mccall John W.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260427
Subject(s) - anthelmintic , chemistry , benzimidazole , purine , purine metabolism , pharmacology , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , medicine , ecology , biology
A series of methyl 2‐substituted purine 8‐carbamates was prepared and evaluated for antifilarial activity. These purines were synthesized as aza congeners of benzimidazole carbamates which have shown significant anthelmintic activity to determine the effect that this modification might have on anthelmintic activity. The compounds were tested against the filarial infection, B. pahangi , in jirds. None of the compounds prepared in this study demonstrated antifilarial activity.