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Organic phosphorus compounds. Part 3 . Synthesis of 5‐fluorosubstituted benzothiazolylbenzylphosphonates
Author(s) -
Yoshino Kohichiro,
Hori Noriyuki,
Hori Manabu,
Morita Tominori,
Tsukamoto Goro
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260425
Subject(s) - chemistry , phosphorus , coronary vasodilator , key (lock) , combinatorial chemistry , organic chemistry , vasodilation , medicine , ecology , biology
The regio specific synthesis of 5‐fluorobenzothiazoles 14 has been accomplished by using difluorothiobenzanilides 13 as a key intermediate. Through this method, 5‐fluorosubstituted fostedil 3 and its derivatives were synthesized and evaluated coronary vasodilator activity.