Premium
Organic phosphorus compounds. Part 3 . Synthesis of 5‐fluorosubstituted benzothiazolylbenzylphosphonates
Author(s) -
Yoshino Kohichiro,
Hori Noriyuki,
Hori Manabu,
Morita Tominori,
Tsukamoto Goro
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260425
Subject(s) - chemistry , phosphorus , coronary vasodilator , key (lock) , combinatorial chemistry , organic chemistry , vasodilation , medicine , ecology , biology
The regio specific synthesis of 5‐fluorobenzothiazoles 14 has been accomplished by using difluorothiobenzanilides 13 as a key intermediate. Through this method, 5‐fluorosubstituted fostedil 3 and its derivatives were synthesized and evaluated coronary vasodilator activity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom