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Pyrrolo[1,4]benzodiazepines. IV. Synthesis of E ‐ and Z ‐5,11‐dioxo‐11a‐ethoxycarbonyl‐2‐ethylidene‐1,2,3,10,11,11a‐hexahydro‐5 H ‐pyrrolo[2,1‐ c ][1,4]benzodiazepine
Author(s) -
De Caprariis P.,
De Martino G.,
Abignente E.,
Avara P.,
Mayol L.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260423
Subject(s) - chemistry , pyrrole , nitro , stereochemistry , medicinal chemistry , organic chemistry , alkyl
Preparation of the title compound starting from 4‐acetyl‐2,2‐diethoxycarbonyl‐2,3‐dihydro‐1‐(2‐nitro‐benzoyl)‐1 H ‐pyrrole by selective reduction is described; its E and Z forms were isolated and their geometrical structure assigned on the basis of 1 H and 13 C nmr spectral data.