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Pyridazines. XLI synthesis of novel pyrido[3,4‐ d ]pyridazine derivatives from 4,5‐disubstituted pyridazines
Author(s) -
Boamah Philip Yaw,
Haider Norbert,
Heinisch Gottfried
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260410
Subject(s) - pyridazine , chemistry , moiety , pyridine , medicinal chemistry , stereochemistry , aryl , organic chemistry , alkyl
Pyrido[3,4‐ d ]pyridazines 2–5, 21 bearing one, two, or three aryl substituents in the pyridine moiety are shown to be conveniently accessible from 4‐aroyl‐5‐methylpyridazines or 4,5‐diaroylpyridazines, respectively, by condensation reactions with appropriate C‐N fragments. In addition, the novel pyridazine‐annelated pyridones 24, 25 were found to be easily available from ethyl 5‐methyl‐4‐pyridazinecarboxylate.