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Methylfuroquinolinones: New furocoumarin isosters as potential photoreagents toward dna
Author(s) -
Guiotto A.,
Chilin A.,
Pastorini G.,
Palumbo M.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260407
Subject(s) - furocoumarin , chemistry , molar absorptivity , ring (chemistry) , dna , yield (engineering) , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , physics , materials science , optics , metallurgy
A number of methylfuro[3,2‐ g ]quinolin‐7(8 H )‐ones, which can be considered isosters of methylpsoralens, were synthesized. The synthesis was performed starting from the appropriate methyl quinolin‐2‐ones on which the methylfuran ring was condensed. The molar absorptivity at long wavelengths of these compounds is remarkably higher than that of the corresponding methylpsoralen isosters; this fact may lead to an improved photo‐binding to the biological targets.