Synthesis of certain substituted pyrimidines as potential schistosomicidal agents | Zendy

ElKerdawy M. M. | Zendy; ElEmam A. A. | Zendy; ElSubbagh H. I. | Zendy; Abushanab E. | Zendy

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Synthesis of certain substituted pyrimidines as potential schistosomicidal agents

Author(s) -

ElKerdawy M. M.,

ElEmam A. A.,

ElSubbagh H. I.,

Abushanab E.

Publication year - 1989

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570260406

Subject(s) - chemistry , hydroxymethyl , pyrimidine , stereochemistry , medicinal chemistry

A convenient route is reported for the synthesis of seven new pyrimidine derivatives namely: 2‐bromometh‐yl‐4,6‐dimethoxypyrimidine ( 3 ), 2‐dibromomethyl‐4,6‐dimethoxypyrimidine ( 4 ), 2‐acetoxymethyl‐4,6‐dimeth‐oxypyrimidine ( 5 ), 2‐hydroxymethyl‐4,6‐dimethoxypyrimidine ( 6 ), 4,6‐dimethoxypyrimidine‐2‐carboxaldehyde ( 7 ), 2‐acetoxymethyl‐6‐methoxy‐3,4‐dihydropyrimidin‐4‐one ( 8 ) and 2‐hydroxymethyl‐3,4‐dihydro‐6‐methoxy‐pyrimidin‐4‐one ( 9 ).

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