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Synthesis of certain substituted pyrimidines as potential schistosomicidal agents
Author(s) -
ElKerdawy M. M.,
ElEmam A. A.,
ElSubbagh H. I.,
Abushanab E.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260406
Subject(s) - chemistry , hydroxymethyl , pyrimidine , stereochemistry , medicinal chemistry
A convenient route is reported for the synthesis of seven new pyrimidine derivatives namely: 2‐bromometh‐yl‐4,6‐dimethoxypyrimidine ( 3 ), 2‐dibromomethyl‐4,6‐dimethoxypyrimidine ( 4 ), 2‐acetoxymethyl‐4,6‐dimeth‐oxypyrimidine ( 5 ), 2‐hydroxymethyl‐4,6‐dimethoxypyrimidine ( 6 ), 4,6‐dimethoxypyrimidine‐2‐carboxaldehyde ( 7 ), 2‐acetoxymethyl‐6‐methoxy‐3,4‐dihydropyrimidin‐4‐one ( 8 ) and 2‐hydroxymethyl‐3,4‐dihydro‐6‐methoxy‐pyrimidin‐4‐one ( 9 ).