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Synthesis and 1 H‐, 13 C‐NMR analysis of some substituted 1,2,3,4‐tetrahydroisoquinolines
Author(s) -
Ibañez A. F.,
Yaculiano G. B.,
Iglesias G. Y. Moltrasio
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260405
Subject(s) - chemistry , chemical shift , conformational isomerism , carbon 13 nmr , nuclear magnetic resonance spectroscopy , hydrogen , proton , spectral line , proton nmr , nmr spectra database , carbon 13 nmr satellite , stereochemistry , fluorine 19 nmr , molecule , organic chemistry , physics , astronomy , quantum mechanics
Synthesis and 1 H‐, 13 C‐nmr analysis of some substituted 3‐phenyl‐1,2,3,4‐tetrahydroisoquinolines are reported. Spectroscopy assignments of hydrogen and carbon resonances were made on the basis of standard chemical shift theory, comparison with reference compounds, attached proton test and fully coupled 13 C‐nmr spectra. Data showed that at room temperature two conformers predominated for the 1,3‐disubstituted and 1,2,3‐trisubstituted isoquinolines.