A versatile route to potential dihydrofolate reductase inhibitors  via  the hitherto unknown 6‐benzyl‐2‐( O ‐methyl)uracils: Synthesis of isotrimethoprim | Zendy

Botta Maurizio | Zendy; Artico Marino | Zendy; Massa Silvio | Zendy; Gambacorta Augusto | Zendy

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A versatile route to potential dihydrofolate reductase inhibitors via the hitherto unknown 6‐benzyl‐2‐( O ‐methyl)uracils: Synthesis of isotrimethoprim

Author(s) -

Botta Maurizio,

Artico Marino,

Massa Silvio,

Gambacorta Augusto

Publication year - 1989

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570260372

Subject(s) - chemistry , dihydrofolate reductase , uracil , pyrimidine , derivative (finance) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , enzyme , dna , financial economics , economics

The synthesis of 2, 4‐diamino‐6‐(3, 4, 5‐trimethoxybenzyl)pyrimidine (isotrimethoprim) has been accomplished starting from 2‐( O ‐methyl)‐6‐(3, 4, 5‐trimethoxybenzyl)uracil by standard procedures. The benzyluracil derivative has been obtained by reacting O ‐methylisourea sulphate and ethyl 3, 4, 5‐trimethoxyphenacetylace‐tate.

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