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Studies on pyrazines. 18 . A new and convenient synthesis of 2‐amino‐3‐cyanopyrazine
Author(s) -
Sato Nobuhiro
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260357
Subject(s) - chemistry , trimethylsilyl cyanide , trimethylsilyl , cyanide , combinatorial chemistry , organic chemistry , stereochemistry , catalysis
The titled compound, 2‐amino‐3‐cyanopyrazine ( 1 ), was prepared by reaction of 3‐aminopyrazine 1‐oxide ( 7 ) with trimethylsilyl cyanide. Furthermore, conditions of individual steps in synthetic route to 7 starting from 2‐pyrazinecarboxamide were optimized.