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Studies of benzylisoquinolines. Comparison of the reactivity of the methylene group in 1‐benzyl and 4‐benzylisoquinolines
Author(s) -
Vaccher Claude,
Berthelot Pascal,
Devergnies Monique,
Debaert Michel,
Bonte JeanPaul,
Viel Claude
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260356
Subject(s) - chemistry , methylene , reactivity (psychology) , hydroxylamine , reagent , papaverine , medicinal chemistry , organic chemistry , medicine , alternative medicine , pathology
While examining the oxidation of 4‐benzylisoquinolines to the corresponding 4‐benzoylisoquinolines as well as the reactivity of these ketones towards hydroxylamine, reduction reagents and Grignard's reagents, there was found a definite difference in the behavior of the methylene group for these compounds as compared to that of papaverine (1‐benzylisoquinolines).