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A facile one pot synthesis of 1‐alkylbenzimidazoline‐2‐thiones
Author(s) -
Lee Tae Ryong,
Kim Kyongtae
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260344
Subject(s) - chemistry , alkyl , halide , sodium , nitrogen , cleavage (geology) , medicinal chemistry , bond cleavage , organic chemistry , polymer chemistry , catalysis , geotechnical engineering , fracture (geology) , engineering
Reactions of benziraidazoline‐2‐thione with alkyl halides in the presence of sodium naphthalenide in tetra‐hydrofuran at room temperature under a nitrogen atmosphere afforded 1‐alkyl‐2‐alkylthiobenzimidazoles in excellent yields, which underwent a bond cleavage between S and C of alkyl group to give excellent yields of 1‐alkylbenzimidazoline‐2‐thiones by the treatment with an additional amount of sodium naphthalenide.