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Diels‐alder reactions of 3, 6‐diphenyl‐1, 2, 4, 5‐tetrazine and 3, 6‐di(2‐pyridyl)‐1, 2, 4, 5‐tetrazine with some 1‐morpholinocycloalkenes
Author(s) -
Atfah M. Adnan
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260336
Subject(s) - tetrazine , chemistry , pyridazine , aromatization , morpholine , medicinal chemistry , hydrogen peroxide , pyrazine , computational chemistry , organic chemistry , catalysis
The reactions of 3, 6‐diphenyl‐1, 2, 4, 5‐tetrazine 1 and 3, 6‐di(2‐pyridyl)‐1, 2, 4, 5‐tetrazine 2 with the enamines 3a‐d derived from morpholine and the 5‐,6‐,7‐ and 8‐membered cyclic ketones have been investigated. A number of pyridazine derivatives 4–7 most of which are new have been reported. Moreover, a novel procedure for the aromatization of pyridazines 5a‐d to the corresponding pyridazine 7b‐d via oxidative elimination using hydrogen peroxide is described. The structures of products 4–7 were confirmed by spectral methods and elemental analysis.