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Synthesis of substituted tetrahydropyrimido‐[4, 5‐ b ][1, 7]naphthyridines as potential antitumor agents
Author(s) -
Gangjee Aleem,
Donkor Isaac O.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260333
Subject(s) - chemistry , carbon 13 nmr , stereochemistry , catalysis , combinatorial chemistry , organic chemistry
The synthesis of two linear trisubstituted 6, 7, 8, 9‐tetrahydropyrimido[4, 5‐ b ][1, 7]naphthyridines 1 and 3 were accomplished by the regiospecific cyclocondensation of two disubstituted 6‐aminopyrimidines 10 and 11 with the ketoaldehyde 1‐benzyl‐4‐hydroxymethylene‐3‐piperidone. Catalytic debenzylation of 1 afforded the disubstituted compound 2 . The linear structures of 1–3 were established by 1 H nmr and 13C nmr.