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Syntheis of 2‐aryloxy‐ and 2‐arylalkoxy‐1‐(2‐piperidyl)ethanols
Author(s) -
Mauleón David,
Pujol M. Dolors,
Minguillón Cristina,
Miquel Jaume
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260331
Subject(s) - chemistry , thionyl chloride , diastereomer , hydrolysis , alkaline hydrolysis , medicinal chemistry , organic chemistry , chloride
The preparation and separation of diastereomeric pairs of a series of 2‐aryloxy‐ and 2‐arylalkoxy‐1‐(2‐piperidyl)ethanols is reported. The erythro aminoalcohols were converted into threo isomers by thionyl chloride treatment of their N ‐acetyl derivatives and alkaline hydrolysis.
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