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Synthesis of 1, 5‐ and 1, 7‐dichloro‐9 H ‐thioxanthen‐9‐ones
Author(s) -
Okabayashi Ichizo,
Murakami Née Iwata Noriko,
Sekiya Kaoru
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260323
Subject(s) - chemistry , chlorobenzene , benzoic acid , thio , sulfuric acid , condensation , medicinal chemistry , organic chemistry , catalysis , thermodynamics , physics
Abstract 1, 5‐Dichloro‐9 H ‐thioxanthen‐9‐one ( 2 ) was prepared by cyclization of 2‐chloro‐6‐[(2‐chlorophenyl)thio]‐benzoic acid ( 10 ) obtained from 2‐chloro‐6‐iodobenzoic acid ( 9 ) and 2‐chlorobenzenethiol. Similarly, 1, 7‐di‐chloro‐9 H ‐thioxanthen‐9‐one ( 6 ) was prepared from 9 via 2‐chloro‐6‐[(4‐chlorophenyl)thio]benzoic acid ( 11 ). Compound 6 was also obtained by condensation of 2‐chloro‐6‐mercaptobenzoic acid ( 12 ) with chlorobenzene in the presence of sulfuric acid.