Palladium‐catalyzed furylation and thienylation of activated alkenes with 2‐furoyl chloride and 2‐thenoyl chloride | Zendy

Kasahara Akira | Zendy; Izumi Taeko | Zendy; Ogihara Takao | Zendy

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Palladium‐catalyzed furylation and thienylation of activated alkenes with 2‐furoyl chloride and 2‐thenoyl chloride

Author(s) -

Kasahara Akira,

Izumi Taeko,

Ogihara Takao

Publication year - 1989

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570260315

Subject(s) - chemistry , palladium , decarbonylation , catalysis , chloride , amine gas treating , medicinal chemistry , organic chemistry

2‐Furoyl or 2‐thenoyl chlorides readily react with activated alkenes in the presence of a tertiary amine and a catalytic amount of palladium(II) acetate to give 2‐furylated or 2‐thienylated alkenes. Under similar conditions, 2‐benzofuroyl chloride undergoes facile alkenylation to produce 2‐alkenylated benzofurans. The reaction involves a highly efficient decarbonylation of furoyl or thenoyl‐palladium species.

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