Synthesis and in solution behaviour of new 2‐substituted‐4‐thiazolidinecarboxylic acid derivatives | Zendy

Chiarino D. | Zendy; Ferrario F. | Zendy; Pellacini F. | Zendy; Sala A. | Zendy

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Synthesis and in solution behaviour of new 2‐substituted‐4‐thiazolidinecarboxylic acid derivatives

Author(s) -

Chiarino D.,

Ferrario F.,

Pellacini F.,

Sala A.

Publication year - 1989

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570260313

Subject(s) - diastereomer , chemistry , thiazolidine , ring (chemistry) , center (category theory) , stereochemistry , organic chemistry , combinatorial chemistry , crystallography

A number of 2‐substituted‐4‐thiazolidinecarboxylic acid derivatives were synthesized by cyclocondensation of L‐cysteine or its esters with various aldehydes, resulting from acids provided with antiinflammatory properties. In the cyclocondensation a new chiral center at C‐2 position of thiazolidine ring is formed giving rise to a mixture of diastereoisomers which can be partially separated. These diastereoisomers show in solution a fast epimerisation at the same chiral center as evidenced by 1 H‐nmr studies.

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