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An improved synthesis of indazole‐3‐carboxylic acid
Author(s) -
Ferrari Marinella,
Ripa Alberto,
Ripa Giorgio,
Sisti Massimo
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260251
Subject(s) - chemistry , indazole , chloral hydrate , carboxylic acid , hydrazine (antidepressant) , hydroxylamine hydrochloride , hydrate , hydroxylamine , hydrochloride , organic chemistry , chromatography , psychology , psychiatry
Abstract A new and efficient synthesis of indazole‐3‐carboxylic acid is reported. The method consists in reacting β‐acetylphenylhydrazine with chloral hydrate and hydroxylamine hydrochloride in acidic medium to afford N ‐acetylaminoisonitrosoacetanilide which, in turn, is converted into the title compound by treatment with sulphuric acid.