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Synthesis and spectral data of pyrido[2,3‐ e ]‐ as ‐triazines
Author(s) -
Pié N.,
Quéguiner G.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260242
Subject(s) - chemistry , hydrazine (antidepressant) , medicinal chemistry , triazine , cndo/2 , stereochemistry , organic chemistry , molecule , chromatography
The pyrido[2,3‐ e ]‐ as ‐triazine and its 3‐phenyl derivatives were prepared via cyclisation with polyphosphoric acid of suitable 3‐substituted 2‐aminopyridines obtained by reduction of the corresponding 2‐nitropyridines. The 3‐substituted 2‐nitropyridines were obtained by action of hydrazine or benzoylhydrazide with the appropriate 3‐halo‐2‐nitropyridines; only 3‐fluoro‐2‐nitropyridine leads to the 3‐substituted 2‐nitropyridines. This experimental results are in agreements with the CNDO and MNDO calculations.