Synthesis of antimicrobial agents.  IV . synthesis of 1‐hydroxypiperazine dihydrochloride and its applications to pyridone carboxylic acid antibacterial agents | Zendy

Uno Toshio | Zendy; Okuno Toshimi | Zendy; Taguchi Masahiro | Zendy; Iuchi Koji | Zendy; Kawahata Yoshihiro | Zendy; Sotomura Mikio | Zendy; Tsukamoto Goro | Zendy

Premium

Synthesis of antimicrobial agents. IV . synthesis of 1‐hydroxypiperazine dihydrochloride and its applications to pyridone carboxylic acid antibacterial agents

Author(s) -

Uno Toshio,

Okuno Toshimi,

Taguchi Masahiro,

Iuchi Koji,

Kawahata Yoshihiro,

Sotomura Mikio,

Tsukamoto Goro

Publication year - 1989

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570260223

Subject(s) - chemistry , carboxylic acid , antimicrobial , antibacterial activity , antibacterial agent , combinatorial chemistry , antibiotics , organic chemistry , bacteria , biochemistry , genetics , biology

1‐Hydroxypiperazine dihydrochloride 7 was prepared and it was applied to the syntheses of new pyridone carboxylic acid antibacterial agents (PCA‐antibacterial agents). 1‐Cyclopropyl‐6,8‐difluoro‐1,4‐dihydro‐7‐(4‐hydroxypiperazin‐1‐yl)‐4‐oxoquinoline‐3‐carboxylic acid 13 showed the most potent antibacterial activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research