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Synthesis of antimicrobial agents. IV . synthesis of 1‐hydroxypiperazine dihydrochloride and its applications to pyridone carboxylic acid antibacterial agents
Author(s) -
Uno Toshio,
Okuno Toshimi,
Taguchi Masahiro,
Iuchi Koji,
Kawahata Yoshihiro,
Sotomura Mikio,
Tsukamoto Goro
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260223
Subject(s) - chemistry , carboxylic acid , antimicrobial , antibacterial activity , antibacterial agent , combinatorial chemistry , antibiotics , organic chemistry , bacteria , biochemistry , genetics , biology
1‐Hydroxypiperazine dihydrochloride 7 was prepared and it was applied to the syntheses of new pyridone carboxylic acid antibacterial agents (PCA‐antibacterial agents). 1‐Cyclopropyl‐6,8‐difluoro‐1,4‐dihydro‐7‐(4‐hydroxypiperazin‐1‐yl)‐4‐oxoquinoline‐3‐carboxylic acid 13 showed the most potent antibacterial activity.