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Synthesis of 6 H ,8 H ‐isoquino[2,3‐ c ][1,3]benzothiazin‐8‐ones
Author(s) -
Fodor Lajos,
Szabó János,
Bernáth Gábor,
Sohár Pál,
Maclean David B.,
Smith Richard W.,
Ninomiya Ichiya,
Naito Takeaki
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260212
Subject(s) - chemistry , mass spectrum , sulfur , methylene , benzothiazine , medicinal chemistry , stereochemistry , organic chemistry , ion
6 H ,8 H ‐Isoquino‐1,3‐benzothiazin‐8‐ones have been prepared by reaction of 6,7‐dimethoxy‐2 H ‐1,3‐benzo‐thiazines with homophthalic anhydride and by photocyclization of 3‐benzoyl‐4‐methylene‐6,7‐dimethoxy 2 H ‐1,3‐benzothiazine. The compounds are thia analogues of protoberberine alkaloids containing a sulfur atom at C‐5 and a lactam function at C‐8. The mass spectra of the title compounds are discussed.