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Reactions of 2‐, 3‐, and 4‐( N ‐nitroso)methylaminopyridine with esters containing active methylene groups
Author(s) -
Kiriazis L.,
Kalatzis E.,
Alexandrou N. E.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260128
Subject(s) - chemistry , malonate , methylene , nitroso , nitroso compounds , medicinal chemistry , organic chemistry
2‐ N ‐Nitrosomethylaminopyridine but not 2‐methylaminopyridine, 3‐ N ‐nitrosomethylamino‐ or 3‐methyl‐aminopyridine and 4‐ N ‐nitrosomethylamino‐ or 4‐methylaminopyridine react with malonate esters to form the corresponding derivatives of carbamates, amides and dihydropyridines respectively. In the reaction of the 4‐isomers with diisopropyl malonate small amounts of the corresponding carbamates was also formed.