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The synthesis of β‐heteroarylamino‐α,β‐dehydro‐α‐amino acid and β‐heteroarylamino‐α‐amino acid derivatives
Author(s) -
Svete Jurij,
Stanovnik Branko,
Tišler Miha,
Golič Ljubo,
Leban Ivan
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260127
Subject(s) - chemistry , oxazole , amino acid , catalytic hydrogenation , catalysis , organic chemistry , stereochemistry , biochemistry
From heteroarylaminomethyleneoxazolones 4 , obtained from N ‐heteroarylformamidines 2 and 2‐phenyl‐5‐oxo‐4,5‐dihydro‐1,3‐oxazole ( 3 ), the following β‐heteroarylamino‐α,β‐dehydro‐α‐amino acid derivatives were prepared: methyl 8 and ethyl esters 9 , amides 10 and 11 , hydrazides 12 , and azides 15 . By catalytic hydrogenation the compounds 4 were converted into β‐heteroarylamino substituted amides 18 and β‐heteroarylamino‐α‐amino acids 20 .