Novel resolution of chiral lactams | Zendy

Ürögdi László | Zendy; Kisfaludy Lajos | Zendy; Patthy Ágnes | Zendy; Vezér Csilla | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Novel resolution of chiral lactams

Author(s) -

Ürögdi László,

Kisfaludy Lajos,

Patthy Ágnes,

Vezér Csilla

Publication year - 1989

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570260124

Subject(s) - aminolysis , chemistry , lactam , enantiomer , optically active , derivative (finance) , resolution (logic) , organic chemistry , combinatorial chemistry , chiral auxiliary , stereochemistry , enantioselective synthesis , catalysis , artificial intelligence , computer science , financial economics , economics

A practical method of resolving chiral lactams, e.g. 1 , has been evolved, based on the hydroxymethylation of the lactam, followed by esterification of the product 2 with an optically active N ‐protected amino acid derivative, e.g. N ‐benzyloxycarbonylphenylalanine pentafluorophenyl ester 3 . Chromatographic separation of the unreacted hydroxymethylated lactam 2 and the ester 4 and subsequent dehydroxymethylation of the former and aminolysis of the latter afforded pure enantiomer, ( R )‐ 1 and ( S )‐ 1 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research