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O ‐Alkylations of pyridoxine and pyridoxamine
Author(s) -
Ueda Taisei,
Nakaya Kenji,
Nagai ShinIchi,
Sakakibara Jinsaku
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260108
Subject(s) - chemistry , pyridoxamine , sodium ethoxide , pyridoxine , acetone , alkoxy group , medicinal chemistry , sodium , potassium , methyl iodide , organic chemistry , pyridoxal , alkyl , biochemistry , phosphate , ethanol
O ‐Alkylations of pyridoxine 1 and pyridoxamine 5 were carried out in acetone in the presence of sodium ethoxide and potassium iodide to give 5‐alkoxy‐6‐methyl‐3,4‐(bishydroxymethyl)pyridines 2a‐j and 5‐alkoxy‐4‐aminomethyl‐6‐methyl‐3‐hydroxyrnethylpyridines 6a‐e .
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