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A facile one step synthesis of novel ethyl 2,6‐bis(trifluoromethyl)‐4‐hydroxypyrimidine‐5‐carboxylate
Author(s) -
Sing Y. Larry,
Lee Len F.
Publication year - 1989
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570260102
Subject(s) - chemistry , trifluoromethyl , carboxylate , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , alkyl
Trifluoroacetonitrile was condensed with diethyl malonate to give a novel ethyl 2,6‐bis(trifluoromethyl)‐4‐hydroxypyrimidine‐5‐carboxylate ( 2 ) in 88% yield. Derivations of 2 are also described.