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Synthesis of 2/6‐(polychloromethyl)pyridine‐carboxylates
Author(s) -
Chupp John P.,
Smith Lowell R.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250636
Subject(s) - chemistry , pyridine , chloride , combinatorial chemistry , organic chemistry
Due to their relationship to certain bio‐active 2,6‐(polyfluoromethyl)‐3,5‐pyridinedicarboxylates 12 , methodology was developed to prepare new, but analogous 2/6 (polychloromethyl)pyridinecarboxylates 6, 9, 10, 13, 18 and 20. Successful methods to prepare these materials include several chlorination procedures, mixed Hantzsch sequences, and aluminum chloride interchanges with 12 and 16.