Premium
Synthesis of 2/6‐(polychloromethyl)pyridine‐carboxylates
Author(s) -
Chupp John P.,
Smith Lowell R.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250636
Subject(s) - chemistry , pyridine , chloride , combinatorial chemistry , organic chemistry
Due to their relationship to certain bio‐active 2,6‐(polyfluoromethyl)‐3,5‐pyridinedicarboxylates 12 , methodology was developed to prepare new, but analogous 2/6 (polychloromethyl)pyridinecarboxylates 6, 9, 10, 13, 18 and 20. Successful methods to prepare these materials include several chlorination procedures, mixed Hantzsch sequences, and aluminum chloride interchanges with 12 and 16.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom