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The reaction of 2‐substituted‐4,5‐dichloro‐3(2 H )‐pyridazinones with alkoxides and alkylthiolates
Author(s) -
Lyga John W.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250629
Subject(s) - chemistry , solvent , chlorine atom , medicinal chemistry , chlorine , displacement (psychology) , organic chemistry , psychology , psychotherapist
The reaction of 2‐substituted‐4,5‐dichloro‐3(2 H )‐pyridazinones 1a‐b with alkoxides and alkylthiolates was investigated. Regiospecific displacement of either the 4 or 5 chlorine atom could be achieved in most cases by appropriate selection of the reaction solvent.