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Investigation of the reactions of 2‐hydrazino‐benzimidazoles with β‐diketones: Synthesis of 2‐(3,5‐disubstituted‐ 1 H ‐pyrazol‐1‐yl)benzimidazoles
Author(s) -
Joshi Krishna C.,
Jain Renuka,
Dandia Anshu,
Sharma Kanti
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250608
Subject(s) - chemistry , alkylation , elemental analysis , proton nmr , benzimidazole , medicinal chemistry , spectral analysis , organic chemistry , catalysis , spectroscopy , physics , quantum mechanics
Reaction of 2‐hydrazinobenzimidazoles with β‐diketones in neutral and acidic media revealed that 2‐(3,5‐disubstituted‐1 H ‐pyrazol‐1‐yi)benzimidazoles are formed in the former case, whereas hydrazones are obtained in acidic medium. Further the alkylation of > NH of the title compound was investigated. Characterisation of these products have been done by elemental analysis, ir, pmr, 19 F nmr, 13 C nmr and mass spectral studies.