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Convenient synthesis of 3‐methyl‐1‐(4‐pyridinyl)‐2‐butanone using phenyllithium as a metalating agent
Author(s) -
Léon P.,
GarbayJaureguiberry C.,
Roques B. P.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250554
Subject(s) - phenyllithium , chemistry , acylation , alkyl , butanone , organic chemistry , stereochemistry , medicinal chemistry , solvent , catalysis
3‐Methyl‐1‐(4‐pyridinyl)‐2‐butanone has been synthesized via a short and convenient method based upon acylation of 4‐picoline by phenyllithium followed by reaction with ethyl isobutyrate. This procedure can be extended to the preparation of various alkyl pyridyl ketones, intermediates in the synthesis of potential anti‐tumor 6‐substituted 7 H ‐pyridocarbazole dimers.