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Synthesis and studies of piperidinone, the major metabolite of a new antidepressant drug S 3344
Author(s) -
Berthelot Pascal,
Vaccher Claude,
Devergnies Monique,
Flouquet Nathalie,
Debaert Michel
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250550
Subject(s) - chemistry , metabolite , antidepressant , isopropyl , drug , stereochemistry , pharmacology , organic chemistry , biochemistry , neuroscience , psychology , medicine , hippocampus
The synthesis of 1‐(4‐fluorobenzyl)‐6‐isopropyl‐2‐piperidinone 7a , a major metabolite of a new antidepressant S 3344, is described and then substituted with various substituents. The 1 H and 13 C nmr provide information on their structure.
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