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A convenient synthesis of functionalized 1 H ‐pyrimidine‐2‐thiones
Author(s) -
Akcamur Yunus,
Altural Behzat,
Saripinar Emin,
Kollenz Gert,
Kappe Oliver,
Peters Karl,
Peters EvaMaria,
Von Schnering HansGeorg
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250529
Subject(s) - chemistry , furan , pyrimidine , hydrolysis , carbon disulfide , carbon skeleton , organic chemistry , carbon dioxide , medicinal chemistry , combinatorial chemistry , stereochemistry
The furan‐2,3‐dione 1 and the thiosemicarbazones 2 combine with loss of carbon dioxide and water yielding the 1‐methylenaminopyrimidine‐2‐thione derivatives 3 in moderate yields (30–60%). Their molecular skeleton is confirmed with aid of an X‐ray structure determination of 3c . Hydrolysis of 3 leads to the 1‐aminopyrimidine‐2‐thione 5 .