A convenient synthesis of functionalized 1 H ‐pyrimidine‐2‐thiones | Zendy

Akcamur Yunus | Zendy; Altural Behzat | Zendy; Saripinar Emin | Zendy; Kollenz Gert | Zendy; Kappe Oliver | Zendy; Peters Karl | Zendy; Peters EvaMaria | Zendy; Von Schnering HansGeorg | Zendy

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A convenient synthesis of functionalized 1 H ‐pyrimidine‐2‐thiones

Author(s) -

Akcamur Yunus,

Altural Behzat,

Saripinar Emin,

Kollenz Gert,

Kappe Oliver,

Peters Karl,

Peters EvaMaria,

Von Schnering HansGeorg

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250529

Subject(s) - chemistry , furan , pyrimidine , hydrolysis , carbon disulfide , carbon skeleton , organic chemistry , carbon dioxide , medicinal chemistry , combinatorial chemistry , stereochemistry

The furan‐2,3‐dione 1 and the thiosemicarbazones 2 combine with loss of carbon dioxide and water yielding the 1‐methylenaminopyrimidine‐2‐thione derivatives 3 in moderate yields (30–60%). Their molecular skeleton is confirmed with aid of an X‐ray structure determination of 3c . Hydrolysis of 3 leads to the 1‐aminopyrimidine‐2‐thione 5 .

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