A new and convenient synthesis of  N ‐substituted perhydroazepines from adipaldehyde and primary amines with tetracarbonylhydridoferrate, HFe(CO)       4    −    , as a selective reducing agent | Zendy

Shim Sang Chul | Zendy; Doh Chil Hoon | Zendy; Kim Tae Jeong | Zendy; Lee Hak Ki | Zendy; Kim Ki Doo | Zendy

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A new and convenient synthesis of N ‐substituted perhydroazepines from adipaldehyde and primary amines with tetracarbonylhydridoferrate, HFe(CO) 4 − , as a selective reducing agent

Author(s) -

Shim Sang Chul,

Doh Chil Hoon,

Kim Tae Jeong,

Lee Hak Ki,

Kim Ki Doo

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250522

Subject(s) - chemistry , primary (astronomy) , alkyl , carbon monoxide , transformation (genetics) , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , biochemistry , physics , astronomy , gene

Ethanolic tetracarbonylhydridoferrate combined with adipaldehyde is very efficient for the selective transformation of an amino group into perhydroazepine. A large variety of both aliphatic and aromatic amines react with adipaldehyde in the presence of tetracarbonylhydridoferrate at room temperature and carbon monoxide to give the corresponding N ‐alkyl‐ and N ‐arylperhydroazepines in good to excellent yields.

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