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On 6‐(thenoyl)‐7,8‐dichloro‐4‐oxo‐4 H ‐1‐benzopyran‐2‐carboxylic acid
Author(s) -
Montanari Paola,
Da Re Paolo,
Valenti Piero
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250448
Subject(s) - chemistry , benzopyran , ring (chemistry) , carboxylic acid , pyrone , annulation , stereochemistry , bicyclic molecule , medicinal chemistry , organic chemistry , catalysis
Abstract The annulation of the oxyacetic chain of thienylic acid into a γ‐pyrone ring is described. The resulting 6‐(2‐thenoyl)‐7,8‐dichloro‐4‐oxo‐4 H ‐1‐benzopyran‐2‐carboxylic acid retains almost 80% of the diuretic activity of the parent compound.