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A new and convenient synthesis of alkyl and aryl pyrimidines
Author(s) -
Martínez A. García,
Herrera A.,
Martínez R.,
Teso E.,
García A.,
Osío J.,
Pargada L.,
Unanue R.,
Subramanian L. R.,
Hanack Michael
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250437
Subject(s) - chemistry , nitrile , alkyl , aryl , medicinal chemistry , tetra , organic chemistry
Vinyl triflates 1, which are obtained easily from the corresponding ketones, react in an excess of pure nitrile (80°/20 hours) to form tri‐ and tetra‐substituted alkyl and arylpyrimidines 4 and 5 in good yields (45–87%). An isomeric mixture of pyrimidines 4 and 5 is formed from Inflate 1 when R 1 ≠ R 2 ≠ H. The reaction proceeds by nitrile‐catalyzed elimination‐addition mechanism.